In addition to overseeing the U.S. Mint and Fort Knox, Treasurer Lynn Malerba will run the Treasury's new Office of Tribal and Native Affairs.
The plan includes training for federal lenders about working with farmers and ranchers who work inside the borders of tribal nations.
The Indian Health Service has to have its budgets approved by Congress every year.
The deal marks a shift in how tribes are treated when they seek financial restitution from corporations in the courts.
The agency is partnering with groups aiming to add more buffalo to tribal diets and to create an heirloom seed repository, among others.
A Harvard policy paper out this week on the government's pandemic relief effort calls on the Treasury Department to create a dedicated tribal affairs office.
The American Rescue Plan provides $20 billion in aid, but problems with the previous CARES Act rollout have made tribes vigilant.
Tribal governments were already making a successful push to vaccinate people, but these resources will help with even more.
There was a financial imperative for the name change, as sponsors and retailers threatened to pull their money and stop selling team merchandise.
Critics ask why it took so long.